Predictive Methods in Percutaneous Absorption

• Main Authors: Moss, Gary P. (Author), Gullick, Darren R. (Author), Wilkinson, Simon C. (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2015.
• Subjects: Medicine.; Human physiology.; Pharmacology.; Dermatology.; Biomathematics.; Biomedicine.; Pharmacology/Toxicology.; Human Physiology.; Physiological, Cellular and Medical Topics.

This book sheds new light on the development and use of quantitative models to describe the process of skin permeation. It critically reviews the development of quantitative predictive models of skin absorption and discusses key recommendations for model development. Topics presented include an intr...

Table of Contents:

• Skin Structure and Physiology
• Methods for the Measurement of Percutaneous Absorption
• Mathematical Treatments and Early Models of Skin Permeability
• “Building error upon error”: The New Breadth of Research in the Field
• Algorithms for Estimating Permeability Across Artificial Membranes
• Other Approaches to Modelling Percutaneous Absorption
• “Squiggly lines and random dots – you can fit anything with a non-linear model”
• Finite-dose models of transient exposures and volatile formulation components
• “The Devil Is in the Detail …”
• Conclusions and Recommendations for Model Development and Use.