Study of the Calcium Regulation Mechanism of TCR Activation Using Nanodisc and NMR Technologies

• Main Author: Bi, Yunchen (Author, http://id.loc.gov/vocabulary/relators/aut)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2018.
• Edition: 1st ed. 2018.
• Series: Springer Theses, Recognizing Outstanding Ph.D. Research,
• Subjects: Biomedical engineering.; Biophysics.; Biological physics.; Cell membranes .; Immunology.; Atomic structure .; Molecular structure .; Biomedical Engineering and Bioengineering.; Biological and Medical Physics, Biophysics.; Membrane Biology.; Atomic/Molecular Structure and Spectra.

This thesis describes the use of biophysical and biochemical methods to prove that calcium has a positive feedback effect on amplifying and sustaining CD3 phosphorylation and should enhance T-cell sensitivity to foreign antigens. The study presented shows that calcium can regulate the signal pathway...

Table of Contents:

• Introduction
• Review
• Nanodisc assembly and the study on the interaction between the lipid and ion
• Calcium regulates T cell receptor activation through phospholipid electrostatic manipulation
• The preliminary study on the structure of Dengue Virus NS2B-NS3p in complex with aprotinin
• Summary and prospect of this dissertation.