Structural Bioinformatics of Membrane Proteins

• Main Author: Frishman, Dmitrij (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Vienna : Springer Vienna, 2010.
• Subjects: Computer science.; Chemistry, Physical and theoretical.; Bioinformatics.; Systems biology.; Computer Science.; Computational Biology/Bioinformatics.; Systems Biology.; Theoretical and Computational Chemistry.

This book is the first one specifically dedicated to the structural bioinformatics of membrane proteins. With a focus on membrane proteins from the perspective of bioinformatics, the present work covers a broad spectrum of topics in evolution, structure, function, and bioinformatics of membrane prot...

Table of Contents:

• Evolutionary origins of membrane proteins
• Molecular archeological studies of transmembrane transport systems
• Resource for structure related information on transmembrane proteins
• Topology prediction of membrane proteins: how distantly related homologs come into play
• Transmembrane beta-barrel protein structure prediction
• Multiple alignment of transmembrane protein sequences
• Prediction of re-entrant regions and other structural features beyond traditional topology models
• Dual-topology: one sequence, two topologies
• Predicting the burial/exposure status of transmembrane residues in helical membrane proteins
• Helix-helix interaction patterns in membrane proteins
• Predicting residue and helix contacts in membrane proteins
• Natural constraints, folding, motion, and structural stability in transmembrane helical proteins
• Prediction of three-dimensional transmembrane helical protein structures
• GPCRs: Past, present, and future.