Clinical Pharmacology: Current Topics and Case Studies

Today we witness an eventful time in which the powerful new forces of genomics, information technology and economics are rapidly changing the science and art of medicine. This will require more specialization than ever before. However, there is also an increasing demand for an integrated approach, w...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
Άλλοι συγγραφείς: Müller, Markus (Επιμελητής έκδοσης)
Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: Vienna : Springer Vienna, 2010.
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
LEADER 03790nam a22004335i 4500
001 978-3-7091-0144-5
003 DE-He213
005 20151125201853.0
007 cr nn 008mamaa
008 110203s2010 au | s |||| 0|eng d
020 |a 9783709101445  |9 978-3-7091-0144-5 
024 7 |a 10.1007/978-3-7091-0144-5  |2 doi 
040 |d GrThAP 
050 4 |a RM1-950 
072 7 |a MMG  |2 bicssc 
072 7 |a MED071000  |2 bisacsh 
082 0 4 |a 615  |2 23 
245 1 0 |a Clinical Pharmacology: Current Topics and Case Studies  |h [electronic resource] /  |c edited by Markus Müller. 
264 1 |a Vienna :  |b Springer Vienna,  |c 2010. 
300 |a XXIV, 430 p.  |b online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
347 |a text file  |b PDF  |2 rda 
505 0 |a The discipline of Clinical Pharmacology -- Current issues in drug development -- Current issues in drug regulation -- Current issues in drug reimbursement -- Clinical Trials -- Ethics in clinical research -- Good Clinical Practice (GCP) and scientific misconduct -- Phase-I studies and first-in-human trials -- Clinical trials - interventional studies -- Observational studies -- Pharmacokinetics I: PK-PD approaches - antibiotic drug development -- Pharmacokinetics II: 14C-labelled microdosing in assessing drug pharmacokinetics at Phase-0 -- Epidemiology and bio statistics -- Placebo effects and placebo control in clinical trials -- Tools in Clinical Pharmacology -- Tools in clinical pharmacology - imaging techniques -- Current concepts of pharmacogenetics, pharmacogenomics, and the “druggable” genome -- Biomarkers -- Molecular tools in drug research — translational medicine -- Topics in Clinical Pharmacology -- Pharmaceutical drug safety -- Drug interactions medicine -- “Non-chemical” drugs: biologicals, protein therapeutics, vaccines and antisense therapeutics -- Development of Advanced Therapy Medicinal Products — a case for early scientific advice -- Individualized medicine -- Generics, biosimilars, enantiomers and me-toos -- Special situations, market fragmentation I: orphan drugs for rare diseases -- Special situations, market fragmentation II: sex differences -- Special situations III: Medicines for Children. 
520 |a Today we witness an eventful time in which the powerful new forces of genomics, information technology and economics are rapidly changing the science and art of medicine. This will require more specialization than ever before. However, there is also an increasing demand for an integrated approach, which is provided by the discipline of Clinical Pharmacology (CP). CP pursues a scientific goal by studying drug action in patients and volunteers, a clinical goal by administering appropriate drug therapy and a regulatory goal by assessing the risk/benefit ratio of drug candidates in drug development and reimbursement. This introduction to current topics of CP covers traditional topics of clinical drug research and trial methodology but also provides insight in current topics like genomics, imaging technology and issues in drug reimbursement. A number of concrete case studies in clinical drug research and development help to give a better understanding of the general principles of CP. 
650 0 |a Medicine. 
650 0 |a Pharmacy. 
650 0 |a Pharmacology. 
650 1 4 |a Biomedicine. 
650 2 4 |a Pharmacology/Toxicology. 
650 2 4 |a Pharmacy. 
700 1 |a Müller, Markus.  |e editor. 
710 2 |a SpringerLink (Online service) 
773 0 |t Springer eBooks 
776 0 8 |i Printed edition:  |z 9783709101438 
856 4 0 |u http://dx.doi.org/10.1007/978-3-7091-0144-5  |z Full Text via HEAL-Link 
912 |a ZDB-2-SBL 
950 |a Biomedical and Life Sciences (Springer-11642)