Jak-Stat Signaling : From Basics to Disease

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Decker, Thomas (Επιμελητής έκδοσης), Müller, Mathias (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Vienna : Springer Vienna : Imprint: Springer, 2012.
• Θέματα: Life sciences.; Cancer research.; Medical genetics.; Immunology.; Hematology.; Cell biology.; Stem cells.; Life Sciences.; Stem Cells.; Cell Biology.; Cancer Research.; Gene Function.

JAK tyrosine kinases and STAT transcription factors constitute a signaling pathway, which is activated by cytokines. By activating gene transcription it regulates essential biological responses to environmental cues. The Jak-Stat pathway is involved in the regulation of cell development, differentia...

Πίνακας περιεχομένων:

• The continuing fascination with Jaks and Stats: An introduction
• Regulation of JAKs: Insights gleaned from the functional protein domains
• Nuclear functions of the Janus Kinases
• Self-association of STAT proteins from monomers to paracrystals
• How Stats interact with the molecular machinery of transcriptional activation
• Nongenomic Functions of STAT3 .-Evolution of Jak and Stat proteins
• JAK/STAT and chromatin regulation in Drosophila . JAK/STAT signaling and invertebrate immune responses
• Stat5 as a hematopoietic master regulator for differentiation and neoplasia development
• Regulation of dendritic cell development by STATs
• STAT transcription factors – Controlling all aspects of NK cell biology
• Function of JAKs and STATs in lymphocytes: Bench to bedside
• The role of Janus kinases in hematopoietic malignancies
• Activation of Janus kinases during tumorigenesis . STAT1 and STAT3 transcription factors in inflammation-associated colon cancer
• Universal and specific functions of STAT3 in solid tumours
• Impact of STAT5 on normal tissue development and cancer
• Crosstalk with the Jak-STAT pathway in inflammation
• Activation and inhibition of JAK-STAT signal transduction by RNA viruses
• Multifaceted antiviral actions of interferon-stimulated gene products
• Interferon regulation of the innate response to bacteriaEvolution of Jak and Stat proteins
• JAK/STAT and chromatin regulation in Drosophila . JAK/STAT signaling and invertebrate immune responses
• Stat5 as a hematopoietic master regulator for differentiation and neoplasia development
• Regulation of dendritic cell development by STATs
• STAT transcription factors – Controlling all aspects of NK cell biology
• Function of JAKs and STATs in lymphocytes: Bench to bedside
• The role of Janus kinases in hematopoietic malignancies
• Activation of Janus kinases during tumorigenesis . STAT1 and STAT3 transcription factors in inflammation-associated colon cancer
• Universal and specific functions of STAT3 in solid tumours
• Impact of STAT5 on normal tissue development and cancer
• Crosstalk with the Jak-STAT pathway in inflammation
• Activation and inhibition of JAK-STAT signal transduction by RNA viruses
• Multifaceted antiviral actions of interferon-stimulated gene products
• Interferon regulation of the innate response to bacteria.