Store-operated Ca2+ entry (SOCE) pathways Emerging signaling concepts in human (patho)physiology /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Groschner, Klaus (Επιμελητής έκδοσης), Graier, Wolfgang F. (Επιμελητής έκδοσης), Romanin, Christoph (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Vienna : Springer Vienna, 2012.
• Θέματα: Medicine.; Human physiology.; Molecular biology.; Cardiology.; Cell biology.; Biophysics.; Biomedicine.; Molecular Medicine.; Cell Biology.; Human Physiology.; Physics of the Cell.

Store-operated Ca2+ entry (SOCE) serves to control essential functions throughout the human body and represents a novel and attractive target for therapeutic intervention. This book provides an extensive overview of the role of SOCE pathways in Molecular Physiology and Cell Biology, as well as their...

Πίνακας περιεχομένων:

• Preface (C. Romanin, W. F. Graier, K. Groschner)
• SECTION 1: SOCE – Fundamental mechanistic concepts
• Introduction (J. W. Putney)
• 1.1 The STIM-Orai pathway
• Structural insights into Ca2+ sensing by stromal interaction molecules (P. B. Stathopulos, M. Ikura)
• 1.2 The STIM-Orai pathway. Orai, the pore-forming subunit of the CRAC channel (P. G. Hogan)
• 1.3 The STIM-Orai pathway. The interactions between STIM and Orai (R. Schindl, M. Fahrner, M. Muik, I. Derler, C. Romanin)
• 1.4 STIM-TRP pathways. The STIM1/Orai/TRPC channels multiple Ca2+ influx complexes (J. H. Hong, M. S. Kim, K. P. Lee, J. P. Yuan, S. Muallem)
• 1.5 STIM-TRP pathways. Function and regulation of TRPC1: Contribution to Ca2+ entry activated by store depletion (I. S. Ambudkar, K. T. Cheng, H. L. Ong, X. Liu)
• 1.6 Microdomain organization and the role of second messengers. Microdomain organization of SOCE signaling (C. Moreno, L. Vaca)
• 1.7 Microdomain organization and the role of second messengers. Store-operated Ca2+ entry: Endogenous messengers and mediators (V. M. Bolotina)
• SECTION 2: SOCE – Crosstalk between organelle and cellular compartments
• Introduction: Ca2+ signaling and gene regulation: An introduction (A. B. Parekh)
• 2.1 New aspects of the contribut ion of ER to SOCE regulation. The role of the ER and ER-plasma membrane junctions in the regulation of SOCE (H. Dingsdale, L. Haynes, G. Lur, A. Tepikin)
• 2.2 New aspects of the contribution of ER to SOCE regulation. The contribution of SERCA to the regulation of SOCE (J. García-Sancho, M. T. Alonso)
• 2.3 New aspects of the contribution of ER to SOCE regulation. TRPC proteins as a link between plasma membrane ion transport and intracellular Ca2+ stores (A. Bavencoffe, M. X. Zhu)
• 2.4 The role of mitochondria in the activation/maintenance of SOCE. Store-operated Ca2+ entry and mitochondria (A. Spät, G. Szanda)
• 2.5 The role of mitochondria in the activation/maintenance of SOCE. Local regulation of plasma membrane channels by mitochondria (N. Demaurex, M. Frieden)
• 2.6 The role of mitochondria in the activation/maintenance of SOCE. The contribution of distinct mitochondrial Ca2+ uptake mechanisms, mitochondrial motility and location to store-operated Ca2+ entry (R. Malli, W. F. Graier)
• 2.7 Tissue specificity. The role of nanospaces between the organellar membranes in smooth muscle Ca2+ signaling (N. Fameli, A. M. Evans, C. van Breemen)
• 2.8 Tissue specificity. SOCE – implications for Ca2+ handling in endothelial cells (L. A. Blatter)
• SECTION 3: SOCE – Molecular and cellular (patho)physiology
• Introduction (J. A. Rosado)
• 3.1 Immune system. SOCE mediated by STIM and Orai genes in immune function and disease (S. Feske)
• 3.2: Cardiovascular system. STIM1/Orai1-mediated store-operated Ca2+ entry in cardiovascular disease (R. K. Motiani, M. Trebak)
• 3.3: Cardiovascular system. TRPC/Orai-containing channels, Na+/Ca2+ + exchanger and Ca2+ handling in hypertension (V. A. Golovina)
• 3.4: Cardiovascular system. SOCE and TRPC/STIM/Orai signaling in cardiac myocytes (H. Watanabe, T. Ohba, H. Ito)
• 3.5: Cardiovascular system. SOCE as a determinant of cardiac pacemaker activity (D.G. Allen, Y. K. Ju, J. Liu, M. S. Imtiaz)
• 3.6: Cardiovascular system. SOCE and Ca2+ handling in platelet dysfunction (J. J. Lopez, G. M. Salido, J. A. Rosado)
• 3.7: Cardiovascular system. Store-operated Ca2+ entry in endothelial pathophysiology (K. Groschner, M. Poteser)
• 3.8: Nervous system. Pathophysiological perspective of neuronal store-operated Ca2+ signaling (S. Bollimuntha, B. Pani, B. B. Singh)
• 3.9: Skeletal muscle. Store-operated Ca2+ entry and STIM/Orai signaling in skeletal muscle (J. A. Stiber, P. B. Rosenberg)
• 3.10: Skeletal muscle. Store-operated channels and Ca2+ handling in muscular dystrophy (U. T. Ruegg, G. Shapovalov, K. Jacobson, J. Reutenauer-Patte, H. Ismail, O. M. Dorchies, P. Avdonin)
• 3.11: Reproductive system. Store-operated Ca2+ entry in germ cells – role in egg activation (Z. Machaty, C. Wang, K. Lee).