Stem Cell Aging: Mechanisms, Consequences, Rejuvenation

• Corporate Author: SpringerLink (Online service)
• Other Authors: Geiger, Hartmut (Editor), Jasper, Heinrich (Editor), Florian, Maria Carolina (Editor)
• Format: Electronic eBook
• Language: English
• Published: Vienna : Springer Vienna : Imprint: Springer, 2015.
• Subjects: Life sciences.; Cancer research.; Immunology.; Hematology.; Stem cells.; Life Sciences.; Stem Cells.; Cancer Research.

Aging of somatic stem cells reduces cell function and results in dysfunctional organs and tissues, making it an underlying cause of diseases associated with aging. It might even be the primary cause for age-associated attrition of tissue function in organs that heavily rely on stem cells for maintai...

Table of Contents:

• Introduction
• Stem cells, aging and longevity (overview)
• General mechanisms of stem cell aging (overview)
• Mechanisms of Stem Cell Aging in Model Organisms
• Yeast: Chronological aging
• Divisional aging
• Primarily germline
• stem cell aging
• Drosophila: Male germ line
• Female germ line
• Somatic stem cells (stress and regulation of hematopoietic precursors, intestinal stem cell aging and regulation). Zebrafish
• Mechanisms of Stem Cell Aging in Mammalian Tissues.-Hematopoietic (Mouse/Human)
• Skin (Mouse/Human)
• Intestine (Mouse/Human)
• Muscle (Mouse/Human)
• Neuronal Tissues (Mouse/Human)
• Diseases of Aging and Stem Cells
• Chronic Myeloid Leukemia and Aging of Hematopoietic Stem Cells (Mouse/Human)
• Wound Healing Repair and Aging of Skin Stem Cells (Mouse/Human)
• Stem Cell Rejuvenation Muscle
• Hematopoietic
• Neuronal.