St. John's Wort and its Active Principles in Depression and Anxiety

• Corporate Author: SpringerLink (Online service)
• Other Authors: Müller, Walter E. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Basel : Birkhäuser Basel, 2005.
• Series: Milestones in Drug Therapy MDT
• Subjects: Medicine.; Neurosciences.; Pharmacology.; Neurology.; Psychiatry.; Psychotherapy.; Plant biochemistry.; Biomedicine.; Pharmacology/Toxicology.; Plant Biochemistry.

Hypericum extract preparations are used extensively in many countries to treat mildly to moderately depressed patients. While this was based previously on traditional experience, extensive research over the last 10 years has given a broad preclinical and clinical basis to justify the use of Hypericu...

Table of Contents:

• and historical overview
• Phytochemistry
• St. John’s Wort and its active principles in depression and anxiety — A critical analysis of receptor binding studies
• Effects on transmitter uptake and their cellular and molecular basis
• Modulation of neurotransmitter release and metabolism
• Efficacy in behavioural models of antidepressant activity
• Comparative preclinical antidepressant activity of isolated constituents
• Hyperforin and efficacy in animal models for anxiety and cognition
• Pharmacokinetics and biopharmaceuticals
• Clinical efficacy in depression
• Clinical efficacy of St. John’s Wort in psychiatric disorders other than depression
• Side effects and drug interactions
• Endocrinology of St. John’s Wort extract.