Turning up the Heat on Pain: TRPV1 Receptors in Pain and Inflammation

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Malmberg, Annika B. (Επιμελητής έκδοσης), Bley, Keith R. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Basel : Birkhäuser Basel, 2005.
• Σειρά: Progress in Inflammation Research
• Θέματα: Medicine.; Immunology.; Neurosciences.; Pharmacology.; Pain medicine.; Cell biology.; Medicine & Public Health.; Pain Medicine.; Pharmacology/Toxicology.; Cell Biology.

Despite tremendous advances in the understanding of the sensory nervous system which have accompanied the recent explosive growth of the neurosciences, rema- ably few innovative medicines directed towards pain and inflammation are ava- able. Indeed, many patients are still prescribed analgesic and a...

Πίνακας περιεχομένων:

• Historical perspective on capsaicin and its receptor
• Hot peppers, pain and analgesics
• Molecular and cellular properties of vanilloid receptors
• Structural determinants of TRPV1 functionality
• TRPV1 distribution and regulation
• Pharmacology and physiology of vanilloid receptors
• Insights into TRPV1 pharmacology provided by non-capsaicin ligands
• Endocannabinoids and vanilloid TRPV1 receptors
• Vanilloid receptor-mediated hyperalgesia and desensitization
• Capsaicin in human experimental pain models of skin, muscle and visceral sensitization
• Vanilloid receptor involvement in disease states
• TRPV1 in gut function, abdominal pain and functional bowel disorders
• TRPV1 in the airways
• Therapeutic potential of vanilloid agonists and antagonists
• TRPV1 agonist-based therapies: mechanism of action and clinical prospects
• TRPV1 agonist therapies in bladder diseases
• TRPV1 antagonists and chronic pain.