Imaging in Drug Discovery and Early Clinical Trials
The impact of genomics on biomedical research and the development of efficient technology platforms allowing for highly parallel compound synthesis and screening procedures have led to a major paradigm shift in drug discovery and development. Efficient tools for the selection and validation of drug...
Συγγραφή απο Οργανισμό/Αρχή: | |
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Άλλοι συγγραφείς: | , , |
Μορφή: | Ηλεκτρονική πηγή Ηλ. βιβλίο |
Γλώσσα: | English |
Έκδοση: |
Basel :
Birkhäuser Basel,
2005.
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Σειρά: | Progress in Drug Research ;
62 |
Θέματα: | |
Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- The drug discovery process
- Imaging modalities: principles and information content
- Magnetic resonance and fluorescence based molecular imaging technologies
- Studying molecular and cellular processes in the intact organism
- Disease phenotyping: structural and functional readouts
- Evaluation of drug candidates: Efficacy readouts during lead optimization
- Risk identification and management: MRI as a research tool in toxicology studies of new chemical entities
- Pharmacokinetic studies with PET
- Imaging bio-markers predictive of disease/therapy outcome: ischemic stroke and drug development
- Clinical drug evaluation using imaging readouts: regulatory perspectives.