Imaging in Drug Discovery and Early Clinical Trials

• Corporate Author: SpringerLink (Online service)
• Other Authors: Herrling, Paul L. (Editor), Matter, Alex (Editor), Rudin, Markus (Editor)
• Format: Electronic eBook
• Language: English
• Published: Basel : Birkhäuser Basel, 2005.
• Series: Progress in Drug Research ; 62
• Subjects: Medicine.; Radiology.; Control engineering.; Robotics.; Mechatronics.; Medicine & Public Health.; Imaging / Radiology.; Control, Robotics, Mechatronics.

The impact of genomics on biomedical research and the development of efficient technology platforms allowing for highly parallel compound synthesis and screening procedures have led to a major paradigm shift in drug discovery and development. Efficient tools for the selection and validation of drug...

Table of Contents:

• The drug discovery process
• Imaging modalities: principles and information content
• Magnetic resonance and fluorescence based molecular imaging technologies
• Studying molecular and cellular processes in the intact organism
• Disease phenotyping: structural and functional readouts
• Evaluation of drug candidates: Efficacy readouts during lead optimization
• Risk identification and management: MRI as a research tool in toxicology studies of new chemical entities
• Pharmacokinetic studies with PET
• Imaging bio-markers predictive of disease/therapy outcome: ischemic stroke and drug development
• Clinical drug evaluation using imaging readouts: regulatory perspectives.