Complement and Kidney Disease

• Corporate Author: SpringerLink (Online service)
• Other Authors: Zipfel, Peter F. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Basel : Birkhäuser Basel, 2006.
• Series: Progress in Inflammation Research
• Subjects: Medicine.; Human physiology.; Immunology.; Medical microbiology.; Internal medicine.; Nephrology.; Cell biology.; Biomedicine.; Cell Biology.; Human Physiology.; Internal Medicine.; Medical Microbiology.

It is evident that a defective or deregulated complement system results in kidney diseases. An important role of complement effector and regulatory proteins in pathological settings of the kidney has been demonstrated. A large panel of distinct human kidney diseases is caused by defective complement...

Table of Contents:

• The complement system in renal diseases
• Complement in renal transplantation
• C1q and the glomerulonephritides: therapeutic approaches for the treatment of complement-mediated kidney diseases
• Complement deficient mice as model systems for kidney diseases
• Non-Shiga toxin-associated hemolytic uremic syndrome
• Role of complement and Factor H in hemolytic uremic syndrome
• Genetic testing in atypical HUS and the role of membrane cofactor protein (MCP; CD46) and Factor I
• Towards a new classification of hemolytic uremic syndrome
• Therapeutic strategies for atypical and recurrent hemolytic uremic syndromes (HUS)
• Complement defects in children which result in kidney diseases: diagnosis and therapy
• The role of complement in membranoproliferative glomerulonephritis
• The experience of a patient advocacy group.