Chemokine Biology — Basic Research and Clinical Application Volume II: Pathophysiology of Chemokines /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Neote, Kuldeep (Editor), Letts, Gordon L. (Editor), Moser, Bernhard (Editor)
• Format: Electronic eBook
• Language: English
• Published: Basel : Birkhäuser Basel, 2007.
• Series: Progress in Inflammation Research
• Subjects: Medicine.; Immunology.; Pharmacology.; Cell biology.; Biomedicine.; Pharmacology/Toxicology.; Cell Biology.

Chemokines play an important role in recruiting inflammatory cells into tissues in response to infection and inflammation. They also play an important role in coordinating the movement of T-cells, B-cells and dentritic cells, necessary to generate an immune response (response to injury, allergens, a...

Table of Contents:

• Chemokines in animal disease models
• Chemokines in animal models of inflammation
• Autoimmune diseases
• Chemokines in allergic responses: eosinophils, basophils, mast cells
• Chemokines as drug targets
• Chemokines as drug targets
• Screening and characterization of cyclic pentapeptide CXCR4 antagonists/inverse agonists using a pheromone responsive reporter gene in Saccharomyces cerevisiae: Utility of G protein coupled receptor constitutively active mutants
• Antagonists of CXCR3: a review of current progress
• IL-8 receptor antagonist: basic research and clinical utility
• Current status of CCR1 antagonists in clinical trials
• Small molecule CCR2 antagonists
• Chemokine axes in hematopoietic stem cell mobilization
• CCR5 antagonists: from discovery to clinical efficacy.