TNF-alpha Inhibitors

• Corporate Author: SpringerLink (Online service)
• Other Authors: Weinberg, Jeffrey M. (Editor), Buchholz, Robin (Editor)
• Format: Electronic eBook
• Language: English
• Published: Basel : Birkhäuser Basel, 2006.
• Series: Milestones in Drug Therapy
• Subjects: Medicine.; Immunology.; Pharmacology.; Dermatology.; Gastroenterology.; Rheumatology.; Biomedicine.; Pharmacology/Toxicology.

Over the last decade, the advent of biologic agents has greatly revolutionized therapeutic medicine in the management of chronic inflammatory diseases, such as rheumatoid arthritis, Crohn’s disease, and psoriasis. Elucidation of the complex web of cytokine network and the roles of these cytokines in...

Table of Contents:

• to TNF/pathophysiology of TNF
• History of development of TNF inhibitors
• Pharmacology of TNF inhibitors
• Etanercept in rheumatology
• Etanercept in dermatology and off-label use
• Infliximab in rheumatology
• Infliximab in dermatology, gastroenterology, and off-label use
• Adalimumab in rheumatology
• Adalimumab in dermatology
• A review of the safety of the tumor necrosis inhibitors infliximab, etanercept, and adalimumab.