Toll-like Receptors in Inflammation

• Corporate Author: SpringerLink (Online service)
• Other Authors: O’Neill, Luke A.J (Editor), Brint, Elizabeth (Editor)
• Format: Electronic eBook
• Language: English
• Published: Basel : Birkhäuser Basel, 2005.
• Series: Progress in Inflammation Research
• Subjects: Medicine.; Immunology.; Medical microbiology.; Pharmacology.; Infectious diseases.; Cell biology.; Biomedicine.; Infectious Diseases.; Medical Microbiology.; Cell Biology.; Pharmacology/Toxicology.

Toll-like receptors (TLRs) are critical mediators of the innate immune response in mammals. This family of receptors recognizes a variety of microbial products or motifs and initiates the host response to infection. Examples include TLR4 which recognizes lipopolysaccharide (LPS) from Gram-negative b...

Table of Contents:

• TLRs as bacterial sensors
• Toll-like receptors and rheumatoid arthritis: is there a connection?
• Toll-like receptor 9 and systemic autoimmune diseases
• Toll-like receptors and airway disease
• Toll-like receptors and vascular disease
• Toll-like receptors and inflammatory bowel disease
• Toll-like receptor signaling in the liver
• Toll-like receptors as key sensors of viral infection
• IRAK-4: A key kinase involved in toll-like receptor signaling and resistance to bacterial infection
• Endogenous regulation of toll-like receptor signalling
• Tuning of inflammatory cytokines and toll-like receptors by TIR8/SIGIRR, a member of the IL-1 receptor family with unique structure and regulation
• Toll-like receptors as pharmacological targets.