Erythropoietins and Erythropoiesis Molecular, Cellular, Preclinical, and Clinical Biology /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Molineux, Graham (Editor), Foote, Mary Ann (Editor), Elliott, Steven G. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Basel : Birkhäuser Basel, 2006.
• Series: Milestones in Drug Therapy MDT
• Subjects: Medicine.; Pharmacology.; Endocrinology.; Sports medicine.; Cell biology.; Biomedicine.; Pharmacology/Toxicology.; Cell Biology.; Sports Medicine.

Research on, and interest in, red blood cell formation spans several centuries and was thought to have peaked in the 1980s with the cloning of the eryth- poietin (EPO) gene. In the years subsequent to the cloning of EPO and its expression as a recombinant protein, much was written about EPO. Althoug...

Table of Contents:

• Background and basic science
• Erythropoiesis: an overview
• Studies of erythropoiesis and the discovery and cloning of recombinant human erythropoietin
• Structural basis for the signal transduction of erythropoietin
• Molecular biology of the erythropoietin receptor in hematopoietic and non-hematopoietic tissues
• Erythropoietin receptor signaling processes
• Clinical pharmacokinetic properties of rHuEPO: a review
• Biology of erythropoietin
• Commercial production of recombinant erythropoietins
• Clinical use of recombinant erythropoietins
• Use of recombinant erythropoietins in the setting of renal disease
• Erythropoietic therapy in the practice of oncology
• Use of recombinant erythropoietins for the treatment of anemia of chronic disease
• Use of erythropoietins in the surgical setting
• Abuse of recombinant erythropoietins by athletes
• Antibodies to endogenous and recombinant erythropoietin
• New molecules and formulations of recombinant human erythropoietin.