Entry Inhibitors in HIV Therapy

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Reeves, Jacqueline D. (Επιμελητής έκδοσης), Derdeyn, Cynthia A. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Basel : Birkhäuser Basel, 2007.
• Σειρά: Milestones in Drug Therapy
• Θέματα: Medicine.; Immunology.; Pharmacology.; Virology.; Infectious diseases.; Pathology.; Cell biology.; Biomedicine.; Pharmacology/Toxicology.; Infectious Diseases.; Cell Biology.

Entry Inhibitors in HIV Therapy presents the current status of this relatively new and highly dynamic class of inhibitors and provides a unique overview of obstacles and considerations for HIV entry inhibition compared to other antiretroviral targets. The introductory chapters of this book present a...

Πίνακας περιεχομένων:

• to entry inhibitors in the management of HIV infection
• The challenge of HIV sequence diversity in the envelope glycoprotein
• Attachment of human immunodeficiency virus to cells and its inhibition
• Inhibitors that target gp120-CD4 interactions
• Inhibitors that target gp120 interactions with coreceptor
• Inhibitors that target fusion
• HIV-1 entry inhibitors as microbicides
• Entry inhibition of HIV-1 subtype C isolates
• The utility of coreceptor typing in the clinic
• Future clinical prospects for entry inhibitors
• Enfuvirtide: from basic science to FDA approval
• Targets for drug development — past and present.