The Immune Synapse as a Novel Target for Therapy

• Corporate Author: SpringerLink (Online service)
• Other Authors: Graca, Luis (Editor)
• Format: Electronic eBook
• Language: English
• Published: Basel : Birkhäuser Basel, 2008.
• Series: Progress in Inflammation Research
• Subjects: Medicine.; Immunology.; Molecular biology.; Pharmacology.; Allergy.; Infectious diseases.; Cell biology.; Biomedicine.; Infectious Diseases.; Cell Biology.; Molecular Medicine.; Pharmacology/Toxicology.; Allergology.

The immune synapse can be compared to a molecular machine that controls T cell activation when getting in contact with an antigen-presenting cell (APC). The immune synapse is involved in the transfer of information across the T cell–APC junction. It plays an essential role in the control and nature...

Table of Contents:

• The immune synapse and T cell activation: regulation by chemokines
• The induction of regulatory T cells by targeting the immune synapse
• Infiltrating the immunological synapse: prospects for the use of altered peptide ligands for the treatment of immune pathology
• Targeting CD4 for the induction of dominant tolerance
• Anti-CD3: from T cell depletion to tolerance induction
• Immune modulation by CD40L blockade
• CTLA-4-immunoglobulin and indoleamine 2,3-dioxygenase in dominant tolerance
• Adhesion molecules as therapeutic targets
• E3 ubiquitin ligases and immune tolerance: Targeting the immune synapse from within?
• FOXP3 biochemistry will lead to novel drug approaches for vaccines and diseases that lack suppressor T cells
• Transforming growth factor-?: From its effect in T cell activation to a role in dominant tolerance
• From mice to men: the challenges of developing tolerance-inducing biological drugs for the clinic.