The Immune Synapse as a Novel Target for Therapy
The immune synapse can be compared to a molecular machine that controls T cell activation when getting in contact with an antigen-presenting cell (APC). The immune synapse is involved in the transfer of information across the T cell–APC junction. It plays an essential role in the control and nature...
Συγγραφή απο Οργανισμό/Αρχή: | |
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Άλλοι συγγραφείς: | |
Μορφή: | Ηλεκτρονική πηγή Ηλ. βιβλίο |
Γλώσσα: | English |
Έκδοση: |
Basel :
Birkhäuser Basel,
2008.
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Σειρά: | Progress in Inflammation Research
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Θέματα: | |
Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- The immune synapse and T cell activation: regulation by chemokines
- The induction of regulatory T cells by targeting the immune synapse
- Infiltrating the immunological synapse: prospects for the use of altered peptide ligands for the treatment of immune pathology
- Targeting CD4 for the induction of dominant tolerance
- Anti-CD3: from T cell depletion to tolerance induction
- Immune modulation by CD40L blockade
- CTLA-4-immunoglobulin and indoleamine 2,3-dioxygenase in dominant tolerance
- Adhesion molecules as therapeutic targets
- E3 ubiquitin ligases and immune tolerance: Targeting the immune synapse from within?
- FOXP3 biochemistry will lead to novel drug approaches for vaccines and diseases that lack suppressor T cells
- Transforming growth factor-?: From its effect in T cell activation to a role in dominant tolerance
- From mice to men: the challenges of developing tolerance-inducing biological drugs for the clinic.