Bone Morphogenetic Proteins: From Local to Systemic Therapeutics

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Vukicevic, Slobodan (Επιμελητής έκδοσης), Sampath, Kuber T. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Basel : Birkhäuser Basel, 2008.
• Σειρά: Progress in Inflammation Research
• Θέματα: Chemistry.; Immunology.; Biotechnology.; Rheumatology.; Orthopedics.; Cell biology.; Cell Biology.

Tissue engineering is gaining interest as it is applied for regeneration of organs to attain their lost function. Although resorbable scaffolds and progenitor cell types are required principles to engineer a functional tissue locally, the inductive signal is a prerequisite to trigger the growth and...

Πίνακας περιεχομένων:

• Development of a novel compression-resistant carrier for recombinant human bone morphogenetic protein-2 (rhBMP-2) and preliminary clinical results
• Use of recombinant human BMP-2 in orthopedic trauma
• The application of recombinant human bone morphogenetic protein on absorbable collagen sponge (rhBMP-2/ACS) to reconstruction of maxillofacial bone defects
• Clinical outcomes using rhBMP-2 in spinal fusion applications
• Bone morphogenetic protein signaling is fine-tuned on multiple levels
• Dissection of bone morphogenetic protein signaling using genome-engineering tools
• Alterations of BMP signaling pathway(s) in skeletal diseases
• Signaling cross-talk by bone morphogenetic proteins
• The role and mechanisms of bone morphogenetic protein 4 and 2 (BMP-4 and BMP-2) in postnatal skeletal development
• The role of bone morphogenetic protein 4 (BMP-4) in tooth development
• Bone morphogenetic protein antagonists and kidney
• Induction of cementogenesis and periodontal ligament regeneration by the bone morphogenetic proteins
• Control of bone mass by sclerostin: Inhibiting BMP- and WNT-induced bone formation
• Bone morphogenetic proteins in cartilage biology
• Systemic administration of bone morphogenetic proteins.