Influenza Virus Sialidase - A Drug Discovery Target

• Corporate Author: SpringerLink (Online service)
• Other Authors: Itzstein, Mark von (Editor)
• Format: Electronic eBook
• Language: English
• Published: Basel : Springer Basel, 2012.
• Series: Milestones in Drug Therapy
• Subjects: Medicine.; Immunology.; Pharmacology.; Virology.; Infectious diseases.; Biomedicine.; Pharmacology/Toxicology.; Infectious Diseases.

Influenza continues to be an ongoing problem despite the existence of vaccines and drugs. Disease outbreaks can occur relatively quickly as witnessed with the recent emergence of the influenza virus A/H1N1 pandemic. The development of new anti-influenza drugs is thus a major challenge. This volume d...

Table of Contents:

• Influenza Virus Virology
• Investigating the interaction between influenza and sialic acid – making and breaking the link
• Enzymology of Influenza Virus Sialidase
• Influenza Virus Sialidase and Structure-Based Drug Design
• The Development of Carbohydrate-based Influenza Virus Sialidase Inhibitors
• The Development of Non-carbohydrate-based Influenza Virus Sialidase Inhibitors
• Clinical Experience with Influenza Virus Sialidase Inhibitors
• Resistance Development to Influenza Virus Sialidase Inhibitors.