Tetramer Stability and Functional Regulation of Tumor Suppressor Protein p53

• Main Author: Kamada, Rui (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Tokyo : Springer Japan : Imprint: Springer, 2012.
• Series: Springer Theses, Recognizing Outstanding Ph.D. Research,
• Subjects: Chemistry.; Bioorganic chemistry.; Medicinal chemistry.; Proteomics.; Bioorganic Chemistry.; Medicinal Chemistry.

This thesis presents the first report of the comprehensive and quantitative analysis of the effects of tumor-derived mutations on the tetrameric structure of tumor suppressor protein p53, which plays a central role in maintaining genomic integrity. Inactivation of p53 via mutation of its gene is a k...

Table of Contents:

• Quantitative analysis for p53 tetramerization domain mutants reveals a low threshold for tumor suppressor inactivation
• Stabilization of mutant tetrameric structures by calixarene derivatives
• Inhibition of the transcriptional activity of p53 through hetero-oligomerization.