Development of Novel Anti-HIV Pyrimidobenzothiazine Derivatives

• Main Author: Mizuhara, Tsukasa (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Tokyo : Springer Japan : Imprint: Springer, 2013.
• Series: Springer Theses, Recognizing Outstanding Ph.D. Research,
• Subjects: Chemistry.; Pharmaceutical technology.; Virology.; Organic chemistry.; Medicinal chemistry.; Organic Chemistry.; Pharmaceutical Sciences/Technology.; Medicinal Chemistry.

The author successfully developed novel anti-HIV PD 404182 derivatives that exhibited submicromolar inhibitory activity against both HIV-1 and HIV-2. His thesis is in three parts. The first part expounds efficient methods for the synthesis of tricyclic heterocycles related to PD 404182 based on the...

Table of Contents:

• Introduction
• Development of Divergent Synthetic Methods of Pyrimidobenzothiazine and Related Tricyclic Heterocycles
• Structure–Activity Relationship Study of PD 404182 Derivatives for the Highly Potent Anti-HIV Agents.- Design and Synthesis of Photoaffinity Probes and Their Application to Target Identification Study of PD 404182
• Conclusion.