Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Agents

• Main Authors: Hirakawa, Akihiro (Author, http://id.loc.gov/vocabulary/relators/aut), Sato, Hiroyuki (http://id.loc.gov/vocabulary/relators/aut), Daimon, Takashi (http://id.loc.gov/vocabulary/relators/aut), Matsui, Shigeyuki (http://id.loc.gov/vocabulary/relators/aut)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Tokyo : Springer Japan : Imprint: Springer, 2018.
• Edition: 1st ed. 2018.
• Series: JSS Research Series in Statistics,
• Subjects: Statistics .; Biostatistics.; Statistics for Life Sciences, Medicine, Health Sciences.; Statistical Theory and Methods.

This book deals with advanced methods for adaptive phase I dose-finding clinical trials for combination of two agents and molecularly targeted agents (MTAs) in oncology. It provides not only methodological aspects of the dose-finding methods, but also software implementations and practical considera...