Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Agents

• Κύριοι συγγραφείς: Hirakawa, Akihiro (Συγγραφέας, http://id.loc.gov/vocabulary/relators/aut), Sato, Hiroyuki (http://id.loc.gov/vocabulary/relators/aut), Daimon, Takashi (http://id.loc.gov/vocabulary/relators/aut), Matsui, Shigeyuki (http://id.loc.gov/vocabulary/relators/aut)
• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Tokyo : Springer Japan : Imprint: Springer, 2018.
• Έκδοση: 1st ed. 2018.
• Σειρά: JSS Research Series in Statistics,
• Θέματα: Statistics .; Biostatistics.; Statistics for Life Sciences, Medicine, Health Sciences.; Statistical Theory and Methods.

This book deals with advanced methods for adaptive phase I dose-finding clinical trials for combination of two agents and molecularly targeted agents (MTAs) in oncology. It provides not only methodological aspects of the dose-finding methods, but also software implementations and practical considera...

Πίνακας περιεχομένων:

• 1. Introduction
• 2. Phase I Trials for Drug Development in Oncology
• 3. A Summary of Dose
• Finding Methods in Standard Phase I Trials
• 4. Phase I Trials for Combination of Two Agents
• 5. Phase I Trials for Joint Assessment of Both Efficacy and Toxicity
• 6. Additional Topics on Adaptive Dose
• Finding Methods.