Molecular Pathogenesis and Treatment of Chronic Myelogenous Leukemia

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Kizaki, Masahiro (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Tokyo : Springer Japan : Imprint: Springer, 2016.
• Έκδοση: 1st ed. 2016.
• Θέματα: Medicine.; Hematology.; Oncology.; Medicine & Public Health.

Molecular Pathogenesis and Treatment of Chronic Myelogenous Leukemia provides a comprehensive understanding of the recent molecular genetics of Chronic Myelogenous Leukemia (CML) and a characterization of the molecular targets for drug development. Included are therapeutic implications, diagnosis, a...

Πίνακας περιεχομένων:

• 1. Identification and Biology of CML Stem Cells.- 2. Molecular Mechanisms of CML Stem Cell Maintenance
• 3. Roles for Signaling Molecules in the Growth and Survival of CML Cells.- 4. Goal of CML Treatment in the Tyrosine Kinase Inhibitor Era.- 5. Biomarkers for Determining the Prognosis of CML
• 6. Updated European Leukemia Net Recommendations for the Management of CML
• 7. Optimal Monitoring of CML Treatment: Molecular and Mutation Analysis
• 8. Recommendations for Management of CML in the Era of Second-Generation TKIs
• 9. Role of New TKIs and Combinations with Interferon-α for the Treatment of CML
• 10. Safety Profiles of First-Line TKIs and Managing Adverse Effects
• 11. Molecular Mechanism of TKI Resistance and Potential Approaches to Overcome Resistance
• 12. Discontinuation of Therapy and Treatment-Free Remission in CML.