Transglutaminases Multiple Functional Modifiers and Targets for New Drug Discovery /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Hitomi, Kiyotaka (Editor), Kojima, Soichi (Editor), Fesus, Laszlo (Editor)
• Format: Electronic eBook
• Language: English
• Published: Tokyo : Springer Japan : Imprint: Springer, 2015.
• Edition: 1st ed. 2015.
• Subjects: Medicine.; Pharmaceutical technology.; Biochemistry.; Enzymology.; Biomedicine.; Pharmaceutical Sciences/Technology.; Animal Biochemistry.

This book presents basic and extensive information on the physiological and pathological significance of the protein-modifying enzymes, transglutaminases, which are involved in multiple biological events by catalyzing a unique and important posttranslational modification reaction, cross-linking of p...

Table of Contents:

• 1 Structure of Transglutaminases. Unique Features Serve Diverse Functions
• 2 Control of Tg Functions Depending on their Localization
• 3 Preferred Substrate Structure of Transglutaminases
• 4 Insights into Transglutaminase 2 Function Gained from Genetically-Modified Animal Models
• 5 Tranglutaminase in Invertebrates
• 6 Formation of Integrin-Binding Site on Polymer of Transglutamination
• 7 Transglutaminase 2-Mediated Gene Regulation
• 8 The Role of Transglutaminase Type 2 in the Regulation of Autophagy
• 9 Transglutaminase 2 and Celiac Disease
• 10 Transglutaminase ii and Metastasis: How Hot is the Link?- 11 Transglutaminases: Expression in Kidney and Relation to Kidney Fibrosis
• 12 Transglutaminases in Bone Formation and Bone Matrix Stabilization
• 13 Transglutaminases and Neurological Diseases
• 14 Transglutaminase; Mechanism by Oxidative Stress
• 15 Blood Coagulation Factor Xiii : A Multifunctional Transglutaminase
• 16 Inhibition of Transglutaminase
• 17 Substrate Engineering of Microbial Transglutaminase for Site-Specific Protein Modification and Bioconjugation.