Heat Shock Factor

This book presents a large amount of information related to the heat shock response and heat shock factor (HSF), describes core observations about molecular mechanisms and pathophysiological roles, and provides fundamental concepts on the basis of information from diverse aspects. This adaptive resp...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
Άλλοι συγγραφείς: Nakai, Akira (Επιμελητής έκδοσης)
Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: Tokyo : Springer Japan : Imprint: Springer, 2016.
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
LEADER 03940nam a22004815i 4500
001 978-4-431-55852-1
003 DE-He213
005 20170517190046.0
007 cr nn 008mamaa
008 160106s2016 ja | s |||| 0|eng d
020 |a 9784431558521  |9 978-4-431-55852-1 
024 7 |a 10.1007/978-4-431-55852-1  |2 doi 
040 |d GrThAP 
050 4 |a QH573-671 
072 7 |a PSF  |2 bicssc 
072 7 |a SCI049000  |2 bisacsh 
082 0 4 |a 571.6  |2 23 
245 1 0 |a Heat Shock Factor  |h [electronic resource] /  |c edited by Akira Nakai. 
264 1 |a Tokyo :  |b Springer Japan :  |b Imprint: Springer,  |c 2016. 
300 |a VIII, 301 p. 73 illus., 14 illus. in color.  |b online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
347 |a text file  |b PDF  |2 rda 
505 0 |a 1 Proteostasis and adaptation to high temperature stress -- 2 Structure and function of the HSF family members -- 3 Regulation of HSF activation and repression -- 4 Transcriptional regulation by HSF -- 5 HSF1 regulation in aging and its role in longevity -- 6 HSF modulates neural development under normal and stress conditions -- 7 HSF maintains sensory organs -- 8 HSF is required for gametogenesis -- 9 HSF Regulates Immune and Inflammatory Response -- 10 Heat shock factors modulate circadian rhythms -- 11 HSF inhibits the progression of age-related neurodegenerative diseases -- 12 HSF and heart diseases -- 13 HSF supports cancer -- 14 HSF1 activation by small chemical compounds for the treatment of neurodegenerative diseases. 
520 |a This book presents a large amount of information related to the heat shock response and heat shock factor (HSF), describes core observations about molecular mechanisms and pathophysiological roles, and provides fundamental concepts on the basis of information from diverse aspects. This adaptive response to high temperature or protein misfolding is a fundamental mechanism to maintain the capacity of protein homeostasis, or proteostasis, and is evolutionally conserved among all living organisms, including bacteria and humans, on the earth. Furthermore, physiological and pathological roles of HSF have been extensively studied in fruit fly, worm, and mouse models. It has been revealed that HSF plays roles in development of the brain, reproductive and sensory organs, and in ageing, inflammation, and circadian rhythm. Analysis of the mechanisms have uncovered that HSF exerts a wide range of effects on gene expression and epigenetic status on the whole genome. Moreover, loss or gain of HSF function is also closely related to protein-misfolding diseases including neurodegenerative diseases, psychiatric diseases, heart diseases, and cancers. Therefore, HSF is now thought to be a promising therapeutic target for treatment of these refractory diseases. For undergraduate students, this is a highly understandable source of information on heart shock response and HSF, covering the basis of HSF biology, the physiological role of HSF, and disease associated with HSF function. This book not only serves as a guide to the heat shock response and HSF for students and young researchers in other fields, but also is a cornerstone for future work in the field related to the heat shock response and HSF. 
650 0 |a Life sciences. 
650 0 |a Human physiology. 
650 0 |a Biochemistry. 
650 0 |a Proteins. 
650 0 |a Cell biology. 
650 1 4 |a Life Sciences. 
650 2 4 |a Cell Biology. 
650 2 4 |a Protein Science. 
650 2 4 |a Human Physiology. 
650 2 4 |a Animal Biochemistry. 
700 1 |a Nakai, Akira.  |e editor. 
710 2 |a SpringerLink (Online service) 
773 0 |t Springer eBooks 
776 0 8 |i Printed edition:  |z 9784431558507 
856 4 0 |u http://dx.doi.org/10.1007/978-4-431-55852-1  |z Full Text via HEAL-Link 
912 |a ZDB-2-SBL 
950 |a Biomedical and Life Sciences (Springer-11642)