Paroxysmal Nocturnal Hemoglobinuria From Bench to Bedside /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Kanakura, Yuzuru (Editor), Kinoshita, Taroh (Editor), Nishimura, Jun-ichi (Editor)
• Format: Electronic eBook
• Language: English
• Published: Tokyo : Springer Japan : Imprint: Springer, 2017.
• Subjects: Medicine.; Immunology.; Hematology.; Medicine & Public Health.

This volume reviews the fundamental understanding of this potentially life-threatening disease and the advances in treatment that have been achieved with the use of the monoclonal antibody eculizumab. Although the PIGA gene has been known for many years, the mechanism of clonal dominance in paroxysm...