Proteostasis and Chaperone Surveillance

• Corporate Author: SpringerLink (Online service)
• Other Authors: Singh, Laishram Rajendrakumar (Editor), Dar, Tanveer Ali (Editor), Ahmad, Parvaiz (Editor)
• Format: Electronic eBook
• Language: English
• Published: New Delhi : Springer India : Imprint: Springer, 2015.
• Subjects: Life sciences.; Proteomics.; Proteins.; Life Sciences.; Protein Science.; Protein Structure.; Protein-Ligand Interactions.

Proteostasis is central to the development of various human diseases caused due to excessive protein misfolding and the disregulation of the protein quality control system. In this book, respected researchers from many leading institutions contribute their insights on proteostasis maintenance. The c...

Table of Contents:

• Part 1: Maintaining Proteostasis
• 1. Structural Allostery and Protein-Protein Interactions of Sin3
• 2. Protein Posttranslational Modifications: Role in Protein Structure, Function and Stability
• 3. Protein Folding and Aggregation: A revisit of basic conception
• Part 2: Proteopathy: Failure of proteostasis
• 4. Protein Folding: From Normal Cellular Function to Pathophysiology
• 5. Protein Misfolding Diseases: In perspective of Gain and loss-of-function
• 6. Amyloid formation in Alzheimer’s disease
• 7. Advances in modulation of Proteopathies, the devil spread from head to toe
• Part 3: Chaperone surveillance of proteopathy
• 8. Small Molecule Osmolytes can Modulate Proteostasis
• 9. Pharmacological Chaperones in Protein Aggregation Disorders.