Neurodegeneration in Multiple Sclerosis

• Corporate Author: SpringerLink (Online service)
• Other Authors: Filippi, Massimo (Editor), Rovaris, Marco (Editor), Comi, Giancarlo (Editor)
• Format: Electronic eBook
• Language: English
• Published: Milano : Springer Milan, 2007.
• Series: Topics in Neuroscience
• Subjects: Medicine.; Neurosciences.; Radiology.; Neuroradiology.; Nuclear medicine.; Neurology.; Medicine & Public Health.; Imaging / Radiology.; Nuclear Medicine.

In multiple sclerosis (MS), conventional magnetic resonance imaging (cMRI) has proved to be a valuable tool to increase diagnostic reliability and to monitor the efficacy of experimental treatment. However, cMRI has limited specificity and accuracy as to the most disabling aspects of the MS patholog...

Table of Contents:

• Background
• Neuropathological Advances in Multiple Sclerosis
• Neurophysiology
• MRI Techniques to Assess Neurodegeneration
• Atrophy
• T1 Black Holes and Gray Matter Damage
• Magnetization Transfer Imaging
• Perfusion MR I
• Diffusion-Weighted Imaging
• Proton MR Spectroscopy
• Functional MRI
• Evaluation of MRI Outcomes
• Validation of MRI Surrogates
• Defining Responders and Non-responders
• Predictive Models in Multimodal Imaging
• Lessons from Other Neurodegenerative Diseases
• Alzheimer’s Disease
• Other Neurodegenerative Conditions
• Incorporation of Other Biomarkers
• Designing MS Trials for Neurodegeneration
• Critical Review of Existing Trials
• Design for the Next Trials of Neurodegeneration.