Transcriptome Analysis Introduction and Examples from the Neurosciences /

• Κύριοι συγγραφείς: Cellerino, Alessandro (Συγγραφέας, http://id.loc.gov/vocabulary/relators/aut), Sanguanini, Michele (http://id.loc.gov/vocabulary/relators/aut)
• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Pisa : Scuola Normale Superiore : Imprint: Edizioni della Normale, 2018.
• Έκδοση: 1st ed. 2018.
• Σειρά: Lecture Notes (Scuola Normale Superiore) ; 17
• Θέματα: Biomathematics.; Bioinformatics.; Systems biology.; Genetics and Population Dynamics.; Computational Biology/Bioinformatics.; Systems Biology.

 The goal of this book is to be an accessible guide for undergraduate and graduate students to the new field of data-driven biology. Next-generation sequencing technologies have put genome-scale analysis of gene expression into the standard toolbox of experimental biologists. Yet, biological interpretation of high-dimensional data is made difficult by the lack of a common language between experimental and data scientists. By combining theory with practical examples of how specific tools were used to obtain novel insights in biology, particularly in the neurosciences, the book intends to teach students how to design, analyse, and extract biological knowledge from transcriptome sequencing experiments. Undergraduate and graduate students in biomedical and quantitative sciences will benefit from this text as well as academics untrained in the subject. 

 Preface -- Introduction: why study transcriptomics? -- 1. Data distribution and visualisation -- 2. Next-generation RNA sequencing -- 3. RNA-seq raw data processing -- 4. Differentially expressed gene detection & analysis -- 5. Unbiased clustering methods -- 6. Knowledge-based clustering methods -- 7. Network analysis -- 8. Mesoscale transcriptome analysis -- 9. Microscale transcriptome analysis -- Bibliography -- Index.