SUMO Regulation of Cellular Processes

• Corporate Author: SpringerLink (Online service)
• Other Authors: Wilson, Van G. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Dordrecht : Springer Netherlands, 2009.
• Subjects: Medicine.; Proteins.; Posttranslational modification.; Cell biology.; Biomedicine.; Biomedicine general.; Protein Science.; Cell Biology.; Posttranslational Modification.

Over a decade ago, a small cellular protein of 12 kDa, with 18% homology to the well-known ubiquitin protein, was co-discovered and termed Small Ubiquitin-like Modifier, or SUMO. Sumoylation is a post-translational modification that utilizes SUMO as the modifier group covalently attached to target s...

Table of Contents:

• Molecular Functions
• to Sumoylation
• SUMO Modification and Transcriptional Regulation
• Emerging Roles for SUMO in mRNA Processing and Metabolism
• SUMO and Chromatin Remodelling
• Functions of SUMO in the Maintenance of Genome Stability
• SUMO and Nucleocytoplasmic Transport
• SUMO Modification of Ion Channels
• The Roles of SUMO in Metabolic Regulation
• Cell Growth Regulation
• The SUMO Pathway in Mitosis
• Wrestling with Chromosomes: The Roles of SUMO During Meiosis
• Sumoylation in Development and Differentiation
• The Role of Sumoylation in Senescence
• Sumoylation and Apoptosis
• Diseases
• The Role of Sumoylation in Neurodegenerative Diseases
• Sumoylation and Its Contribution to Cancer
• SUMO4-Encoded Genetic Susceptibility to Type 1 Diabetes
• Sumoylation in Craniofacial Disorders
• Viral Interplay with the Host Sumoylation System.