Nuclear Receptors Current Concepts and Future Challenges /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Bunce, Chris M. (Editor), Campbell, Moray J. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Dordrecht : Springer Netherlands, 2010.
• Series: Proteins and Cell Regulation ; 8
• Subjects: Medicine.; Endocrinology.; Oncology.; Biochemistry.; Cell biology.; Biomedicine.; Biomedicine general.; Cell Biology.; Animal Biochemistry.

In 1890 a case of myxedema was treated in Lisbon by the implantation of a sheep thyroid gland with the immediate improvement in the patient’s condition. A few years later, medications for the then ill-explained condition of the menopause included tablets made from cow ovaries. In the first quarter o...

Table of Contents:

• Nuclear Receptors an Introductory Overview
• What does Evolution Teach us about Nuclear Receptors?
• Functions of Nuclear Receptors in Insect Development
• The Glucocorticoid Receptor
• Estrogen Receptors: Their Actions and Functional Roles in Health and Disease
• Androgen Receptor
• Thyroid Hormone Receptors
• The Vitamin D Receptor (NR1I1)
• Retinoic Acid Receptors
• PPARs: Important Regulators in Metabolism and Inflammation
• Xenobiotic Receptors CAR and PXR
• Fxr
• Physiological Functions of TR2 and TR4 Orphan Nuclear Receptor
• Nuclear Receptors and ATP Dependent Chromatin Remodeling: A Complex Story
• Non-Genomic Action of Sex Steroid Hormones
• Ligand Regulation and Nuclear Receptor Action
• New Insights to Nuclear Receptor Gene Regulation from Analysis of their Response Elements in Target Genes
• Systems Biology: Towards Realistic and Useful Models of Molecular Networks.