Sarcopenia – Age-Related Muscle Wasting and Weakness Mechanisms and Treatments /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Lynch, Gordon S. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Dordrecht : Springer Netherlands, 2011.
• Θέματα: Medicine.; Geriatrics.; Sports medicine.; Cell biology.; Biomedicine.; Biomedicine general.; Geriatrics/Gerontology.; Cell Biology.; Sports Medicine.; Medicine/Public Health, general.

Some of the most serious consequences of aging are its effects on skeletal muscle. ‘Sarcopenia’, the progressive age-related loss of muscle mass and associated muscle weakness, renders frail elders susceptible to serious injury from sudden falls and fractures and at risk for losing their functional...

Πίνακας περιεχομένων:

• 1.Overview
• 2. Molecular mechanisms of muscle wasting in cancer and ageing: cachexia versus sarcopenia
• 3. Age-related remodeling of neuromuscular junctions
• 4.Motor unit remodeling during aging
• 5. Age-related decline in actomyosin structure and function
• 6. Excitation-contraction coupling in aged skeletal muscle
• 7. Mitochondrial function in aging skeletal muscle
• 8. Fibrosis and skeletal muscle aging
• 9. Nuclear apoptosis and sarcopenia
• 10. Age-related changes in the molecular regulation of skeletal muscle mass
• 11. Genetic variation and skeletal muscle traits: implications for sarcopenia
• 12. Proteomic profiling of aged skeletal muscle
• 13. Aging, exercise and muscle protein metabolism
• 14. Reactive oxygen species generation and skeletal muscle wasting – implications for sarcopenia
• 15. Exercise as a countermeasure for sarcopenia
• 16. Role of contraction-induced injury in age-related muscle wasting and weakness
• 17. Role of IGF-I signaling in age-related changes in skeletal muscle
• 18. Role of myostatin and TGF-beta signaling in skeletal muscle growth and development: implications for sarcopenia
• 19. β-Adrenergic signaling in sarcopenia and other muscle wasting disorders.