Sarcopenia – Age-Related Muscle Wasting and Weakness Mechanisms and Treatments /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Lynch, Gordon S. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Dordrecht : Springer Netherlands, 2011.
• Subjects: Medicine.; Geriatrics.; Sports medicine.; Cell biology.; Biomedicine.; Biomedicine general.; Geriatrics/Gerontology.; Cell Biology.; Sports Medicine.; Medicine/Public Health, general.

Some of the most serious consequences of aging are its effects on skeletal muscle. ‘Sarcopenia’, the progressive age-related loss of muscle mass and associated muscle weakness, renders frail elders susceptible to serious injury from sudden falls and fractures and at risk for losing their functional...

Table of Contents:

• 1.Overview
• 2. Molecular mechanisms of muscle wasting in cancer and ageing: cachexia versus sarcopenia
• 3. Age-related remodeling of neuromuscular junctions
• 4.Motor unit remodeling during aging
• 5. Age-related decline in actomyosin structure and function
• 6. Excitation-contraction coupling in aged skeletal muscle
• 7. Mitochondrial function in aging skeletal muscle
• 8. Fibrosis and skeletal muscle aging
• 9. Nuclear apoptosis and sarcopenia
• 10. Age-related changes in the molecular regulation of skeletal muscle mass
• 11. Genetic variation and skeletal muscle traits: implications for sarcopenia
• 12. Proteomic profiling of aged skeletal muscle
• 13. Aging, exercise and muscle protein metabolism
• 14. Reactive oxygen species generation and skeletal muscle wasting – implications for sarcopenia
• 15. Exercise as a countermeasure for sarcopenia
• 16. Role of contraction-induced injury in age-related muscle wasting and weakness
• 17. Role of IGF-I signaling in age-related changes in skeletal muscle
• 18. Role of myostatin and TGF-beta signaling in skeletal muscle growth and development: implications for sarcopenia
• 19. β-Adrenergic signaling in sarcopenia and other muscle wasting disorders.