Cancer Systems Biology, Bioinformatics and Medicine Research and Clinical Applications /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Cesario, Alfredo (Επιμελητής έκδοσης), Marcus, Frederick (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Dordrecht : Springer Netherlands : Imprint: Springer, 2011.
• Θέματα: Medicine.; Cancer research.; Medical microbiology.; Oncology.; Bioinformatics.; Systems biology.; Biomedicine.; Cancer Research.; Systems Biology.; Medical Microbiology.; Computational Biology/Bioinformatics.

This teaching monograph on systems approaches to cancer research and clinical applications provides a unique synthesis, by world-class scientists and doctors, of laboratory, computational, and clinical methods, thereby establishing the foundations for major advances not possible with current methods...

Πίνακας περιεχομένων:

• PART I – Introduction and background
• 1. Introduction to systems approaches to cancer
• 2. Cancer: clinical background and key challenges
• PART II – Laboratory, clinical, data and educational resources
• 3. Global molecular and cellular measurement technologies
• 4. Cell lines, tissue samples, model organisms, biobanks
• 5. Expression and genetic variation databases for cancer research
• 6. Education and Research Infrastructures
• PART III – Bioinformatics and systems biology analysis
• 7. Mathematical tools in cancer signalling systems biology
• 8. Computational tools for systems biology
• 9. The hallmarks of cancer revisited through systems biology and network modeling
• 10. Systems biology analysis of cell death pathways in cancer: how collaborative and interdisciplinary research helps
• 11. Systems biology, bioinformatics and medicine approaches to cancer progression outcomes
• 12. System dynamics at the physiological and tumour level
• PART IV – Diagnosis, clinical and treatment applications
• 13. Diagnostic and prognostic cancer biomarkers: from traditional to systems approaches
• 14. Systems biology approaches to cancer drug development
• 15. Circadian rhythms and cancer chronotherapeutics
• 16. Clinical applications of systems approaches
• 17. Cancer robustness and therapy strategies
• PART V – Perspectives and conclusions
• 18. Synthetic biology and perspectives
• 19. Conclusions
• Index.