Non-fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases

• Corporate Author: SpringerLink (Online service)
• Other Authors: Rahimi, Farid (Editor), Bitan, Gal (Editor)
• Format: Electronic eBook
• Language: English
• Published: Dordrecht : Springer Netherlands, 2012.
• Subjects: Medicine.; Neurosciences.; Pathology.; Proteins.; Neurobiology.; Biomedicine.; Biomedicine general.; Protein Science.; Protein Structure.

Aberrant protein folding and self-assembly underlie over 30 human diseases called amyloidoses, for which currently there is no cure. The diseases range from tissue-specific to systemic and from genetic to sporadic. Some of the most devastating amyloidoses are those that affect the central nervous sy...

Table of Contents:

• 1. Overview of Fibrillar and Oligomeric Assemblies of Amyloidogenic Proteins
• 2. Pathologic Lesions in Alzheimer disease and Other Neurodegenerative Diseases—Cellular and Molecular Components
• 3. Preparation and Structural Characterization of Pre-fibrillar Assemblies of Amyloidogenic Proteins
• 4. Biological Targeting and Activity of Pre-fibrillar Aβ Assemblies
• 5. The Role of Aβ and Tau Oligomers in the Pathogenesis of Alzheimer’s disease
• 6. Oligomers of α-Synuclein in the Pathogenesis of Parkinson’s Disease
• 7. Cytotoxic Mechanisms of Islet Amyloid Polypeptide in the Pathogenesis of Type-2 Diabetes Mellitus (T2DM)
• 8. Protein Misfolding and Toxicity in Amyotrophic Lateral Sclerosis
• 9. Structural Studies of Prion Proteins and Prions
• 10. Role of Prion Protein Oligomers in the Pathogenesis of Transmissible Spongiform Encephalopathies
• 11. When More Is Not Better: Expanded Polyglutamine Domains in Neurodegenerative Disease
• 12. Protein Misfolding and Toxicity in Dialysis-Related Amyloidosis
• 13. Transthyretin Aggregation and Toxicity
• 14. Strategies for Inhibiting Protein Aggregation: Therapeutic Approaches to Protein-Aggregation Diseases.