Induced Pluripotent Stem Cells in Brain Diseases Understanding the Methods, Epigenetic Basis, and Applications for Regenerative Medicine. /

• Main Authors: Heine, Vivi M. (Author), Dooves, Stephanie (Author), Holmes, Dwayne (Author), Wagner, Judith (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Dordrecht : Springer Netherlands, 2012.
• Series: SpringerBriefs in Neuroscience,
• Subjects: Life sciences.; Neurosciences.; Neurology.; Pediatrics.; Stem cells.; Life Sciences.; Stem Cells.

The principle goal of regenerative medicine is the restoration of damaged, dysfunctional, or missing cellular tissue, up to and including whole organs. Growing healthy replacement tissue, in vivo or in vitro, plays an important role in anticipated therapies. To generate competent replacement materia...

Table of Contents:

• I. Introduction.- II. Cell Reprogramming: A New Era in Regenerative Medicine
• a. Stem Cells
• b. Reprogramming Methods.- c. Measuring Pluripotency, Efficiency, and Identity
• d. Induced Pluripotent Stem Cells versus Embryonic Stem Cells
• III. Understanding Epigenetic Memory is the Key to Successful Reprogramming
• a. Pre-fertilization to Embryo
• b. Epigenetic Control in De-, Re-, and Trans-differentiation
• IV. Prospects for Cell Replacement Therapies for Brain Diseases
• a. Parkinson’s Disease
• b. Childhood Brain White Matter Disorders
• V. Conclusions.- VI. Acknowledgement
• VII. References.