Systems Biology in Biotech & Pharma A Changing Paradigm /

• Main Authors: Prokop, Aleš (Author), Michelson, Seth (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Dordrecht : Springer Netherlands, 2012.
• Series: SpringerBriefs in Pharmaceutical Science & Drug Development, 2
• Subjects: Medicine.; Pharmaceutical technology.; Biotechnology.; Microbiology.; Biomedicine.; Biomedicine general.; Applied Microbiology.; Pharmaceutical Sciences/Technology.

Systems Biology (SB) is a suite of technologies and methodologies that resulted, conceptually from the merging of two basic paradigms, reductionism and holism. It represents a combination of reductionist and holistic approaches to the relationships among the elements of a system, with the goal of id...

Table of Contents:

• Abstract
• 1 Introduction: Discovery & Development - New Facet Of Industry, New Tools And Lead Optimization: 1.1 Scope And Content Of This Review
• 2 Discovery: Use Of Systems Biology For Identifying Targets
• 3 Integrative Systems Biology I - Biochemistry:  Phase I Lead Discovery & Molecular Interactions
• 4 Integrative Systems Biology Ii - Molecular Biology:  Phase 2 Lead Discovery & In Silico Screening
• 5. Discovery: Computational Systems Biology (Csb) In Health & And Disease I
• 6 Development:  In Vivo Pharmacology - Systems Biology In Health & Disease Ii
• 7 Development: Pharmacokinetics – Systems Biology In Health & Disease Iii
• 8 Development:  Multiscale Csb – Simulation Tools
• 9 Development:  Drug Formulation & Delivery
• 10 Development: Preclinical Model Based Drug Development
• 11 Systems Biology: Impact On Pharma And Biotech
• 12 Acknowledgment
• 13 Bibliography.