Phosphoinositides I: Enzymes of Synthesis and Degradation

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Balla, Tamas (Επιμελητής έκδοσης), Wymann, Matthias (Επιμελητής έκδοσης), York, John D. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Dordrecht : Springer Netherlands : Imprint: Springer, 2012.
• Σειρά: Subcellular Biochemistry, 58
• Θέματα: Medicine.; Human genetics.; Medical genetics.; Molecular biology.; Neurosciences.; Neurochemistry.; Biomedicine.; Biomedicine general.; Human Genetics.; Molecular Medicine.; Gene Function.

Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegene...

Πίνακας περιεχομένων:

• 1. The Phosphatidylinositol 4-kinases: Don’t Call it a Comeback
• 2. PIP kinases from the cell membrane to the nucleus
• 3. The Phospholipase C Isozymes and Their Regulation.- 4. Phosphoinositide 3-Kinases – A Historical Perspective
• 5. PI 3-kinases – drug targets in inflammation and cancer
• 6. Phosphoinositide 3-kinases in health and disease
• 7. Phosphoinositide phosphatases: just as important as the kinases
• 8. The PTEN and myobubularin phosphoinositide 3-phosphatases: linking lipid signalling to human disease.