Morphofunctional Aspects of Tumor Microcirculation

• Main Author: Ribatti, Domenico (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Dordrecht : Springer Netherlands : Imprint: Springer, 2012.
• Subjects: Medicine.; Cancer research.; Oncology.; Cell biology.; Biomedicine.; Cancer Research.; Cell Biology.

Blood vessels of tumors display many structural and functional abnormalities. Their unusual leakiness, potential for rapid growth and remodelling, and expression of distinctive surface molecules mediate the dissemination of tumor cells in the bloodstream and maintain the tumor microenvironment. Like...

Table of Contents:

• List of abbreviations
• Introduction
• 1.1.Tumor endothelial cell features
• 1.2. Tumor pericytes
• 1.3. Tumor lymphatic vessels
• 2.1.Tumor angiogenesis
• 2.2.The role of inflammatory cells in tumor angiogenesis
• 2.3. Alternative mode of tumor vascular growth
• 2.4. The role of bone marrow stem cells in tumor angiogenesis
•  3.1. Anti-angiogenic therapy
• 3.2. Metronomic chemotherapy
• 3.3.Combinatorial approach
• 3.4.Vascular targeting to tumor vasculature
• 3.5. Tumor vascular normalization
• 3.6. Drawbacks of anti-angiogenesis therapies
• References.