Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Dey, Aparajita (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Dordrecht : Springer Netherlands : Imprint: Springer, 2013.
• Σειρά: Subcellular Biochemistry, 67
• Θέματα: Medicine.; Pharmacology.; Life sciences.; Biochemistry.; Biomedicine.; Pharmacology/Toxicology.; Life Sciences, general.; Biochemistry, general.

The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1), which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in reg...

Πίνακας περιεχομένων:

• Cytochrome P450 2E1 and its clinical aspects
• Nrf2 and antioxidant defense against CYP2E1 toxicity
• The role of Cytochrome P-4502E1 in ethanol-mediated carcinogenesis
• The Importance of CYP2E1 in the pathogenesis of alcoholic liver disease and drug toxicity and the role of the proteasome
• Relevance of CYP2E1 to non-alcoholic fatty liver disease
• CYP2E1-catalyzed alcohol metabolism
• CYP2E1, oxidative stress, post-translational modifications and  lipid metabolism
• The role of CYP2E1 in alcohol metabolism and sensitivity in the central nervous system.