Prostate Cancer: Shifting from Morphology to Biology
The aim of this book will be to contribute to the education of a new generation of experts in urology, molecular biology, pathology and oncology, offering them sufficient knowledge in basic and translational research to be fluency in the web of interacting networks playing a role in prostate cancer...
| Συγγραφή απο Οργανισμό/Αρχή: | |
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| Άλλοι συγγραφείς: | |
| Μορφή: | Ηλεκτρονική πηγή Ηλ. βιβλίο |
| Γλώσσα: | English |
| Έκδοση: |
Dordrecht :
Springer Netherlands : Imprint: Springer,
2013.
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| Θέματα: | |
| Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- Foreword. Preface. List of contributors. I Clues to morphological diagnosis and prognosis evaluation.-Update on diagnostic criteria, on biopsy and surgical specimen: pre-invasive lesions, from epithelial cell hyperplasia to carcinoma in situ invasive carcinoma. First-line immunophenotyping of prostate diseases
- II Molecular pathology
- Molecular determinants of cancer-related inflammation
- Apoptosis and autophagy
- Androgen receptor and steroidogenesis pathways
- Neuroendocrine differentiation – role of somatostatin receptors (SSTRs) for diagnosis, prognosis, and therapy
- Metastatic dissemination
- Resistance to castration - resistance to drugs
- Crossroads of signaling pathways. III Genetic and Epigenetic Events in prostate cancer
- Gene polymorphisms
- Expression signature
- Mapping prostate cancer aggressiveness loci
- Epigenetic mechanisms: histone acetylation, DNA methylation, miRNA, chromatin modifiers. IV A modern approach to therapy of prostate cancer: targeting the deadly subset.-Molecular markers for patient selection and stratification: personalized prognostic predictive models
- Targeting tumor angiogenesis
- Efficacy of signal transduction inhibition in advanced prostate cancer
- Therapeutic targeting of the bone pre-metastatic niche
- Counteracting hypoxia in radio-resistant metastatic lesions
- “Synthetic lethality”: molecular co-targeting to restore the DNA
- Repair mechanisms in prostate cancer cells concluding remarks. Index.
