Mechanisms of Gene Regulation

• Main Authors: Carlberg, Carsten (Author), Molnár, Ferdinand (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Dordrecht : Springer Netherlands : Imprint: Springer, 2014.
• Subjects: Medicine.; Gene expression.; Proteins.; Biomedicine.; Gene Expression.; Protein Structure.

This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of expression is a fundamental aspect of nearly...

Table of Contents:

• Overview: What is gene expression?
• The impact of chromatin
• The basal transcriptional machinery
• Transcription factors
• Linking signal transduction and gene regulation
• Switching genes on and off at the example of nuclear receptors
• Mapping the genome
• Chromatin modifiers
• Genomic imprinting
• The epigenome
• Chromatin remodeling
• Chromatin architecture
• Regulatory RNA.