Neuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP)

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Fonta, Caroline (Επιμελητής έκδοσης), Négyessy, László (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Dordrecht : Springer Netherlands : Imprint: Springer, 2015.
• Έκδοση: 1st ed. 2015.
• Σειρά: Subcellular Biochemistry, 76
• Θέματα: Medicine.; Human physiology.; Neurosciences.; Developmental biology.; Animal physiology.; Biomedicine.; Human Physiology.; Animal Physiology.; Developmental Biology.

Phosphatases such as TNAP are fundamental in regulating cellular, and consequently numerous body functions. TNAP is a ubiquitous enzyme with a wide spectrum of substrates and specificity regulation at the cellular level and the lack of TNAP activity is a lethal condition. Recent findings of a highly...

Πίνακας περιεχομένων:

• 1 Clinical forms and animal models of hypophosphatasia
• 2 Molecular genetics of hypophosphatasia and phenotype-genotype correlations
• 3 Genetically modified mice for studying TNAP function
• 4 Tissue-Nonspecific Alkaline Phosphatase in the Developing Brain and in Adult Neurogenesis
• 5 Rediscovering TNAP in the brain: a major role in regulating the function and development of the cerebral cortex
• 6 TNAP in the retina
• 7 Tissue Non-specific Alkaline Phosphatase (TNAP) in vessels of the brain
• 8 What can we learn about the neural functions of TNAP from studies on other organs and tissues?
• 9 TNAP, an essential player in membrane lipid rafts of neuronal cells
• 10 Signal transduction pathways of TNAP: molecular network analyses
• 11 Vitamin B-6 Metabolism and Interactions with TNAP
• 12 Tetramisole and levamisole suppress neuronal activity independently from their inhibitory action on Tissue Non-Specific Alkaline Phosphatase in mouse cortex
• 13 TNAP and Pain Control
• 14 Neurological symptoms of Hypophosphatasia
• 15 Recombinant enzyme replacement therapy in hypophosphatasia
• 16 Neurogenetic Aspects of Hyperphosphatasia in Mabry Syndrome
• 17 The role of tissue non-specific alkaline phosphatase (TNAP) in Neurodegenerative diseases: Alzheimer’s disease in the focus
• 18 TNAP plays a key role in neural differentiation as well as in neurodegenerative disorders
• Index.