MACPF/CDC Proteins - Agents of Defence, Attack and Invasion

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Anderluh, Gregor (Επιμελητής έκδοσης), Gilbert, Robert (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Dordrecht : Springer Netherlands : Imprint: Springer, 2014.
• Σειρά: Subcellular Biochemistry, 80
• Θέματα: Medicine.; Pharmacy.; Science.; Chemistry.; Entomology.; Biomedicine.; Biomedicine general.; Medicine/Public Health, general.; Science, general.; Chemistry/Food Science, general.

This book focusses on evolutionary, structural and functional aspects of pore-forming proteins, bringing together prominent researchers in the fields of structural biology and cellular and biophysical techniques. The focus is on the MACPF/CDC protein superfamily that was originally discovered becaus...

Πίνακας περιεχομένων:

• Part I: Overview of MACPF/CDCs
• Introduction: Brief Historical Overview
• Distribution of MACPF/CDC proteins
• Evolution of the Complement System
• Part II: Structures of MACPF/CDCs
• Structural Features of Cholesterol Dependent Cytolysins and Comparison to other MACPF-domain containing proteins
• Perfringolysin O Structure and Mechanism of Pore Formation as a Paradigm for Cholesterol-Dependent Cytolysins
• Structural Biology of the Membrane Attack Complex
• Part III: Functional aspect
•  Membrane Interactions and Cellular Effects of MACPF/CDC Proteins
• The Biology of Pneumolysin
• Multifaceted Activity of Listeriolysin O, the Cholesterol-Dependent Cytolysin of Listeria monocytogenes
• Perforin - a Key Pore-Forming Protein for Immune Control of Viruses and Cancer
• Perforin and Human Diseases
• The role of MACPF Proteins in the Biology of Malaria and other Apicomplexan Parasites
• Chlamydial MACPF Protein CT153
• Fungal MACPF-Like Proteins and Aegerolysins: Bi-Component Pore-Forming Proteins?
• Fluorescence Imaging of MACPF/CDC Proteins: New Techniques and Their Application.