The Biochemistry of Retinoic Acid Receptors I: Structure, Activation, and Function at the Molecular Level

• Corporate Author: SpringerLink (Online service)
• Other Authors: Asson-Batres, Mary Ann (Editor), Rochette-Egly, Cécile (Editor)
• Format: Electronic eBook
• Language: English
• Published: Dordrecht : Springer Netherlands : Imprint: Springer, 2014.
• Series: Subcellular Biochemistry, 70
• Subjects: Medicine.; Science.; Gene expression.; Nutrition.; Health.; Biomedicine.; Biomedicine general.; Gene Expression.; Science, general.; Medicine/Public Health, general.; Popular Science in Medicine and Health.

A role for vitamin A in living organisms has been known throughout human history. In the last 100 years, the biochemical nature of vitamin A and its active derivative, retinoic acid, its physiological impact on growth processes and the essential details of its mechanism of action have been revealed...

Table of Contents:

• Forward
• History of Retinoic Acid Receptors
• Architecture of DNA Bound RAR Heterodimers
• Retinoic Acid Receptors: Structural Basis for Coregulator Interaction and Exchange
• Evolution of Retinoic Acid Receptors and Retinoic Acid Signaling
• RXRs: Collegial Partners
• Nuclear and Extra-Nuclear Effects of Retinoic Acid Receptors: How they are interconnected- The Roles of Retinoic Acid and Retinoic Acid Receptors in Inducing Epigenetic Changes
• RARs and micro RNAs
• Integrative genomics to dissect retinoids functions
• Complexity of the RAR‐Mediated Transcriptional Regulatory Programs
• Index.