Stress Response Pathways in Cancer From Molecular Targets to Novel Therapeutics /
It is now established that dysregulated cell stress response pathways play a critical role in tumorigenesis, and a refined mechanistic understanding of this phenomenon at the molecular level promises to open new avenues for targeted therapeutic strategies that may benefit cancer patients in the near...
| Συγγραφή απο Οργανισμό/Αρχή: | |
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| Άλλοι συγγραφείς: | |
| Μορφή: | Ηλεκτρονική πηγή Ηλ. βιβλίο |
| Γλώσσα: | English |
| Έκδοση: |
Dordrecht :
Springer Netherlands : Imprint: Springer,
2015.
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| Θέματα: | |
| Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- Preface
- Introduction to cell stress responses in cancer: The big picture
- DNA repair dysregulation in cancer: From molecular mechanisms to synthetic-lethal opportunities
- Cell cycle checkpoint defects as anticancer targets: From molecular mechanisms to therapeutic opportunities
- p53 at the crossroads between stress response signaling and tumorigenesis: From molecular mechanisms to therapeutic opportunities
- Sirtuins as a double-edged sword in cancer: From molecular mechanisms to therapeutic opportunities
- MicroRNA regulated stress responses in cancer
- Senescence in oncogenesis: From molecular mechanisms to therapeutic opportunities
- Pro-senescence therapy for cancer: time for the clinic
- Integrating proteotoxic stress response pathways for induction of cell death in cancer cells: molecular mechanisms and opportunities
- The Hsp70 family of heat shock proteins in tumorigenesis: From molecular mechanisms to therapeutic opportunities
- The ubiquitin-proteasome system (UPS) as a cancer drug target: Emerging mechanisms and therapeutics
- Endoplasmatic reticulum stress in multiple myeloma: From molecular mechanisms to therapeutic opportunities
- Melanomagenic gene alterations viewed from a redox perspective: Molecular mechanisms and therapeutic opportunities
- Targeting hypoxic adaptations of cancer cells: Molecular mechanisms and therapeutic opportunities
- Targeting glycolytic adaptations of cancer cells: from molecular mechanisms to therapeutic opportunities
- At the crossroads between mitochondrial metabolite transport and apoptosis: VDAC1 as an emerging cancer drug target
- Inflammatory dysregulation and cancer: From molecular mechanisms to therapeutic opportunities
- Cell-nonautonomous ER stress-mediated dysregulation of immunity by cancer cells
- Index.
