Kinesins and Cancer

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Kozielski, FSB, Frank (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Dordrecht : Springer Netherlands : Imprint: Springer, 2015.
• Θέματα: Medicine.; Cancer research.; Medicinal chemistry.; Oncology.; Proteins.; Cell biology.; Biomedicine.; Cancer Research.; Cell Biology.; Medicinal Chemistry.; Protein-Ligand Interactions.

This interdisciplinary volume collates research work on kinesins and cancer. Authors attempt to validate members of the kinesin superfamily as potential targets for drug development in cancer chemotherapy. The work begins by highlighting the importance of kinesins, summarising current knowledge and...

Πίνακας περιεχομένων:

• Preface
• The kinesin superfamily
• The discovery and development of Eg5 inhibitors for the clinic
• Mechanism of action of Eg5 inhibitors
• Clinical trials of mitotic kinesin inhibitors
• Kif15; a useful target for anti-cancer therapy?.- Down-regulating CENP-E activity: for better or for worse
• The human kinesin-14 motor KifC1/HSET is an attractive anti-cancer drug target.-Kinesin-13 Microtubule Depolymerizing Proteins as targets for cancer therapy
• Chromokinesins in genome maintenance and cancer
• Kif14: a clinically relevant kinesin and potential target for cancer therapy
• Kinesin-8 members and their potential as biomarker or therapeutic target
• The kinesin-6 members MKLP1, MKLP2 and MPP
• Non-motor spindle proteins as cancer chemotherapy targets
• Inhibitors of mitotic kinesins for cancer treatment: consequences for neurons
• Index.