Proteases in Human Diseases

• Corporate Author: SpringerLink (Online service)
• Other Authors: Chakraborti, Sajal (Editor), Chakraborti, Tapati (Editor), Dhalla, Naranjan S. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Singapore : Springer Singapore : Imprint: Springer, 2017.
• Subjects: Medicine.; Cancer research.; Human physiology.; Molecular biology.; Pharmaceutical technology.; Biomedicine.; Human Physiology.; Molecular Medicine.; Pharmaceutical Sciences/Technology.; Cancer Research.

This book bridges the gap between fundamental research and biomedical and pharmacological applications on proteases. It represents a comprehensive overview of the multifaceted field of proteases in cellular environment and highlights the recently elucidated functions of complex proteolytic systems i...

Table of Contents:

• 1. Matrix metalloproteases in breast carcinoma, immunohistology and prognosis
• 2. Matrix metalloproteases in parasite infection
• 3. Cysteine cathepsins: In health and rheumatoid arthritis
• 4. Protective role of antiproteases in radiation induced damage
• 5. Role of proteases in the regulation of N-myristoyltransferase
• 6. Proteases in cancer: Potential therapeutic targets
• 7. MMPs in oral squamous cell carcinoma
• 8. Caspase regulatory mechanisms: Implications in pathogenesis and therapeutics
• 9. Physiological and pathological functions of mitochondrial proteases
• 10. Proteases of parasitic helminths: their metabolic role in establishment of infection in the host
• 11. Cysteine proteases of parasitic helminths
• 12. targeting proteases in urine for bladder cancer diagnosis
• 13. Intramembrane cleaving proteases (ICLiPs), particularly the gamma secretase protease and its role in neurodegeneration, cancer and innate immune signalling
• 14. Contribution of matrix metalloproteases in cardiovascular diseases
• 15. OPG/RANKL-protease axis in cardiometabolic diseases
• 16. Proteases and protease inhibitors in male reproduction
• 17. The role of MMP-2 and -9 in embryonic neural crest cells and their derivatives
• 18. Proteolytic ubiquitin like proteins
• 19. C.albicans aspartic proteases: role of these enzymes in degradation of crucial human host proteins at the place of infection and a possible implications of the protease action for propagation of infection.
• 20. MMPs in cancer
• 21. Pathophysiological roles played by proteases of Psedomonas aeruginosa: crucial multifunctional molecules involved in the host infection
• 22. Role of proteases on activating cell death pathways
• 23. varying faces of matrix metalloproteinases in cardiovascular diseases
• 24. kallikreins and kallikrein related peptides (KLKs) in health and disease
• 25. Endogenous proteases in tumoral progression.